There are a pandemic number of people who are vitamin D deficient. This has become evident due to increased discovery and sharing of documentation from clinical trials, epidemiological studies, and educational journals. The end results from an alarming and growing number due to lack of sunshine exposure and inadequate supply of vitamin D from daily food intake. This added to obesity trends, an aging population, and improved skin products that block formation of vitamin D3. Until recently, vitamin D was understood to be solely related to bone mineralization and calcium utilization in the body. Further studies have revealed vitamin D to play a leading role in many additional cell processes. More than 36 cell types and 10 extra renal organs have been discovered to possess the vitamin D receptor, or VDR. Insufficient vitamin D is related to reduced immunological conditions, cancers of the breast, colon, pancreas, and prostate as well as heart diseases, type I diabetes, rheumatoid arthritis, cognitive impairment, and all cause mortality. This impressive collection of medical conditions accounts for more than 60% of all deaths in the Western World.
What is Vitamin D?
A fat soluble pro-hormone, vitamin D is a seco-steroid which exists in two forms: vitamin D2 & vitamin D3. Vitamin D2 is obtained from yeast and plant material, vitamin D3 is produced endogenously in the skin by the photo-chemical conversion of 7-dehydrocholesterol. Vitamin D circulates in the body bound to the vitamin D binding protein, or VDBP. Both vitamin D2 and D3 are converted to the biomarker 25-hydoxyvitamin [D (25(OH)D] in the liver and undergoes further hydroxylation in the kidneys to the bio-active form of the hormone 1,25(OH)2D.
The Frequency of vitamin D Deficiency:
The March 2010 issue of the Journal of Clinical Endocrinology & Metabolism points towards an overwhelming 59% of people that are vitamin D insufficient. This was based on a cross-sectional study designed to establish a relationship between serum 25(OH)D and the degree of fat penetration in muscle. These results have been duplicated as well in several independent studies of people from all over the United States in recent months.
Adverse Outcomes of Vitamin D Insufficiency:
Presence of 1,25(OH)2D and vitamin D receptors (VDR) in a wide variety of tissues ranging from pancreas, colon, brain, liver, muscle, skin and lung speaks of its newly found broad involvement in the functionality of bodily systems. Published literature over several years indicates that the non-bone mineralization effects of vitamin D are autocrine, not endocrine. Thus, implying these functions are not based or derived for the amount of circulating 1,25(OH)2D in the body, but rather due to the intracellular synthesis of 1,25(OH)2D by these tissues. Studies also indicate that the levels of 1,25(OH)2D required for these non-calcemic functions are higher than the levels of normal serum 1,25(OH)2D.
Epidemiological evidences have linked deprived levels of vitamin D conditions to osteoporosis, osteoarthritis, obesity, multiple sclerosis, hypertension, type I diabetes and several cancers. Vitamin is also effective in maintaining low susceptibility to infections including pulmonary diseases.
Conclusion:
Vitamin D has been shown to have an extensive area of biological influence due to the discovery of VDR and its conversion in several body tissues. Health, strength and athletic performance can be optimized by measuring the residual levels of vitamin D at the cellular level to determine the degree of insufficiencies in order to adjust diets and nutritional supplements which directly influences athletic strength and recovery time.
Contact us for information on measuring residual vitamins & minerals by functional intracellular analysis at the cellular level – which is directly proportional to the body stores . . .
Reference: Ray J, Meike W. D-Light: Vitamin D and Good Health. MLO. 2010;42(5):32-38