Archive for June, 2009

Leptin & Insulin – Vital Hormones for Optimal Health . . .

nutrition | Posted by admin June 22nd, 2009

Each and every one of us is a combination of lives within lives. We are made up of trillions of individual living cells that each must maintain itself. Even more significantly, the cells must communicate and interact with each other to form a republic of cells that we call our individual self. Our health and life depends on how accurately instructions are conveyed to our cells so that they can act in harmony. It is the communication among the individual cells that will determine our health and our life. The communication takes place by hormones. Arguably therefore, the most important molecules in your body that ultimately will decide your health and life are hormones.

Many would say that genes and chromosomes are the most important molecules, however once born your genes pretty much just sit there; hormones tell them what to do. Certainly, the most important message that our cells receive is how and what to do with energy, and therefore life cannot take place without that.

The two most important hormones that deliver messages about energy and metabolism are insulin and leptin.

Metabolism can roughly be defined as the chemistry that turns food into life, and therefore insulin and leptin are critical to health and disease. Both insulin and leptin work together to control the quality of your metabolism (and, to a significant extent, the rate of metabolism).

Insulin works mostly at the individual cell level, telling the vast majority of cells whether to burn or store fat or sugar and whether to utilize that energy for maintenance and repair or reproduction. This is extremely important for on an individual cell level turning on maintenance and repair equates to increased longevity, and turning up cellular reproduction can increase your risk of cancer.

Leptin, on the other hand, controls the energy storage and utilization of the entire republic of cells allowing the body to communicate with the brain about how much energy (fat) the republic has stored, and whether it needs more, or should burn some off, and whether it is an advantageous time nutritionally-speaking for the republic –you– to reproduce or not.

Leptin is a very powerful and influential hormone produced by fat cells. Prior to leptin’s discovery, fat was viewed as strictly an ugly energy storage depot that most everyone was trying to get rid of. After it was discovered that fat produced the hormone leptin (and subsequently it was discovered that fat produced other very significant hormones), fat became an endocrine organ like the ovaries, pancreas and pituitary, influencing the rest of the body and, in particular, the brain.

Leptin, as far as science currently knows, is the most powerful regulator that tells your brain what to do about life’s two main biological goals: eating and reproduction. Your fat, by way of leptin, tells your brain whether you should be hungry, eat and make more fat, whether you should reproduce and even make babies, or (partly by controlling insulin) whether to “hunker down” and work overtime to maintain and repair yourself. In short, leptin is the way that your fat stores speak to your brain to let your brain know how much energy is available and, very importantly, what to do with it. Therefore, leptin may be “on top of the food chain” in metabolic importance and relevance to disease.

It has been known for many years that fat stores are highly regulated. It appeared that when one tried to lose weight the body would try to gain it back. This commonly results in “yo-yo” dieting and in scientific circles one talks about the “set point” of weight. It has long been theorized that there must be a hormone that determines this.

Science points now to leptin as being that hormone.

If a person is getting too fat, the extra fat produces more leptin which is supposed to tell the brain that there is too much fat stored, more should not be stored, and the excess should be burned.

Signals are therefore sent to an area of the brain in the hypothalamus (the arcuate nucleus) to stop being hungry, to stop eating, to stop storing fat and to start burning some extra fat off.

The importance of insulin in health and disease is becoming well-known. Aside from its obvious role in diabetes, it plays a very significant role in hypertension, cardiovascular disease, and cancer.

However leptin may even supersede insulin in importance, for new research is revealing that in the long run glucose and therefore insulin levels may be largely determined by leptin.

It had been previously believed that the insulin sensitivity of muscle and fat tissues were the most important factor in determining whether one would become diabetic or not. Elegant new studies are showing that the brain and liver are most important in regulating a person’s blood sugar levels especially in type 2 or insulin resistant diabetes.

People become leptin-resistant by the same general mechanism that people become insulin-resistant; by overexposure to high levels of the hormone. High blood glucose levels cause repeated surges in insulin, and this causes one’s cells to become “insulin-resistant” which leads to further high levels of insulin and diabetes. It is much the same as being in a smelly room for a period of time. Soon, you stop being able to smell it, because the signal no longer gets through. This is the same happens with leptin. It has been shown that as sugar gets metabolized in fat cells, fat releases surges in leptin, and those surges result in leptin-resistance just as it results in insulin-resistance.

The only known way to reestablish proper leptin (and insulin) signaling is to prevent those surges, and the only known way to do that is via diet and supplements. When leptin signaling is restored, your brain can finally hear the message that perhaps should have been delivered decades ago; high leptin levels can now scream to your brain that you have too much fat and that you better start burning some off for your life is in danger. Your brain will finally allow you access into your pantry that you have been storing your fat in. Your cells will be fed the food from that fat and they will be satisfied. They will not know whether that food came from your belly fat or from your mouth; nor will they care. They will be receiving energy that they need and will not have to ask for more. You will not be hungry.

This also makes counting calories irrelevant, for the calories that you put into your mouth today are not necessarily what your cells will be eating; that will be determined primarily by leptin. Whether or not you put food into your mouth, your cells will be eating, and if they cannot eat fat they must eat sugar. Since little sugar is stored, that sugar will be had by making you crave it, or by turning the protein in your muscle and bone into sugar. This contributes in a major way to weakness and osteoporosis. Whether or not this lean tissue wasting happens is determined by your capacity, or incapacity, to burn fat, and that is determined by your ability to listen to leptin.

When you become leptin-resistant, your body can no longer hear the messages telling it to stop eating and burn fat — so it remains hungry and stores more fat.

Leptin-resistance also causes an increase in visceral fat, sending you on a vicious cycle of hunger, fat storage and an increased risk of heart disease, diabetes, metabolic syndrome and more.

People become both insulin and leptin resistant by eating the typical
American diet full of sugar,refined grains,processed foods and not a whole lot else. The solution is to instead eat a diet that emphasizes good fats and avoids blood sugar spikes — in short a dietary program detailed which emphasizes healthy fats, lean meats and vegetables, and restricts sugar and grains.

Ref: Ron Rosedale, M.D.

Importance of Magnesium – Especially for Athletes

Fitness, nutrition, performance | Posted by admin June 19th, 2009

Most people are aware of the importance of getting enough calcium, which remains a widespread problem. Most people don’t know there are other common micronutrient deficiencies that need to be addressed. Magnesium is one of those important micronutrients that doesn’t seem to get much attention, but plays a huge role in the body promoting health & performance.

Unfortunately the diets of all Americans are likely to be deficient and they don’t even know it. Sources estimate that nearly 70 percent of Americans get inadequate doses of magnesium every day and do not consume the daily recommended amounts of Magnesium. Studies have also shown food alone can’t meet the minimal Recommended Daily Allowances (RDA) micronutrient requirements for preventing nutrient-deficiency diseases. For several years experts have suggested that the availability of magnesium in the soil has significantly decreased and it is difficult to get the amount of magnesium needed to function at an optimal level. This, in combination with diets low in whole grains and fresh fruits and vegetables, has led to a general deficiency in the population.

Magnesium is used for more than 300 bodily functions and assists in energy production, maintains healthy bone density and aids the electrical conduction of the heart. Magnesium belongs in a category of minerals called electrolytes because they conduct electrical signals in the body. It is needed in energy metabolism, glucose utilization, protein synthesis, fatty acid synthesis and breakdown, muscle contraction, all ATPase functions, for almost all hormonal reactions, and in the maintenance of cellular ionic balance. It is found in all of the body’s cells, although it is mostly concentrated in the bones, muscles, and soft tissues. Magnesium also affects calcium’s role in homeostasis through two mechanisms.

Magnesium deficiency results in altered cardiovascular function, including electrocardiographic abnormalities, impaired carbohydrate metabolism, with insulin resistance and decreased insulin secretion, and high blood pressure. Even a mild deficiency causes sensitiveness to noise, nervousness, irritability, mental depression, confusion, twitching, trembling, apprehension, insomnia, muscle weakness and cramps in the toes, feet, legs, or fingers.

In active adults and athletes low magnesium levels can acutely contribute to early fatigue, nausea, muscle cramps & an irregular heartbeat during exercise. Magnesium as well as zinc, chromium and selenium are excreted in the sweat or as part of the process of metabolic acceleration. Heavy sweat loss can interfere with the important functions for which magnesium and other electrolytes are responsible. Also, the rate of magnesium loss is increased in conditions of high humidity and high temperature. An important consideration for athletes is the rate of magnesium loss that occurs during heavy physical activity. Heavy exercise makes you lose magnesium in the urine and scientific evidence suggests this is why long distance runners may suddenly drop dead with heart arrhythmias.

In a very tightly controlled three-month US study carried out last year, the effects of magnesium depletion on exercise performance in 10 women were observed. In the first month, the women received a magnesium-deficient diet (112mgs per day), which was supplemented with 200mgs per day of magnesium to bring the total magnesium content up to the RDA of 310mgs per day. In the second month, the supplement was withdrawn to make the diet magnesium-deficient, but in the third month it was reintroduced to replenish magnesium levels.

At the end of each month, the women were asked to cycle at increasing intensities until they reached 80% of their maximum heart rate, at which time a large number of measurements were taken, including blood tests, ECG and respiratory gas analysis.

The researchers found that, for a given workload, peak oxygen uptake, total and cumulative net oxygen utilization and heart rate all increased significantly during the period of magnesium restriction, with the amount of the increase directly related to the extent of magnesium depletion. In plain English, a magnesium deficiency reduced metabolic efficiency, increasing the oxygen consumption and heart rate required to perform work – exactly what an athlete doesn’t want!

No serious athlete or trainer can afford to overlook the benefits that magnesium brings to athletic performance and the recovery process. Research suggests that even a small shortfall in magnesium can lead to greatly reduced performance and stamina. Many athletic medical specialists believe that magnesium is the single most important mineral to sports nutrition. Not only does it help optimize an athlete’s performance, but it speeds up recovery from fatigue and injuries.

Optimal muscle contraction and relaxation is the foundation of an athlete’s performance. Proper magnesium levels are required for muscles to relax fully following a contraction. Some doctors believe that injuries to hamstring muscles can be partially avoided through intake of magnesium and stated that a shortened hamstring is a result of lack of available magnesium.

The first step is to eat more magnesium rich foods, especially beans, nuts and vegetables. The more active a person is the greater the need to make sure there is a variety of balanced micronutrient-enriched foods into their diet. The challenge is to eat large amounts of magnesium-rich foods on a consistent basis. Often this proves difficult and unrealistic, as an athlete’s requirement of magnesium intake far surpasses that of an average person. Micronutrient supplementation still may be needed to be incorporated into their wellness program as a preventative protocol for preventing these observed deficiencies.

Another important step is to have your levels checked. The residual level of magnesium in the cells is what’s important. The body does all it can to keep the blood levels normal, so if there is a body deficit, it will be found within the cells. Work with a practitioner that will check your RBC-magnesium level (the level of magnesium in red blood cells) or provide an FIA (functional intracellular analysis) for your body’s residual nutrient levels that will benchmark your cell level status to find the amount of supplements needed to achieve normal levels. Recommended intake for endurance athletes is 500 to 800 mg daily.

There is virtually no one that cannot benefit greatly from increasing daily magnesium intake. In terms of health and longevity magnesium is essential. For the professional athlete it means the difference between winning and losing, and in some cases, living and dying.

Suggest: Isotonic Nutraceutical Calcium Complete with Magnesium & Vitamin D3 daily –http://tinyurl.com/25w6hez

Genetics And Performance

performance | Posted by admin June 12th, 2009

Genetics shape us in many ways including our potential to excel in sports. Training, diet, and other factors play a large role in developing our potential, but our genes may also limit performance. You may have the genetic potential for being a champion athlete, but if you live a lifestyle of overeating and no exercise you are unlikely to achieve that potential. On the other hand, someone with limited genetic potential can find ways to compensate and become a solid performer.

Genetics have a large influence over strength, muscle size and muscle fiber composition (fast or slow twitch), anaerobic Threshold, lung capacity, flexibility, and, to some extent, endurance.

One major limitation for endurance athletes is cardiac capacity, or the heart’s ability to deliver enough oxygen (via the bloodstream) to the working skeletal muscles. This, too, is largely determined by genetics.

The other limitation for endurance athletes is the muscles’ ability to effectively use the oxygen and create ATP (adenosine triphosphate), the fuel that allows muscular contraction and movement. The efficiency of this process is measured by something called VO2 max (maximum volume of oxygen).

How Genetics Influence Response to Training
Your genes may also determine how your body responds to training, diet and other external factors.

Research on aerobic endurance shows that some people respond more to training than others. So even if you have a low genetic potential for endurance, you may respond well to training and develop your potential more completely than someone with genetic ‘talent’ who doesn’t respond to training.

Training also increases cardiac efficiency, but the extent of this increase may depend upon genetics. Genetically gifted athletes will have a much greater response to training and will have a large increase in the number of mitochondria in cells. (The mitochondria are organelles in cells that produce the ATP, so the more mitochondria a person has, and the more efficient they are.)

Other Factors That Affect Performance
Characteristics that genetics have less influence over include balance, agility, reaction time and accuracy.

Nutrition also affects performance. This is clear when even the most highly-trained and gifted athlete bonks during an event. Bonking is usually related to running out of glycogen. Athletes can avoid this either by ‘teaching’ the body to burn fat when glycogen stores decrease, or replenishing the body with nutrition during an event.

Mental Skills Training
Practicing mental skills training (including good judgment, learning the tactics and strategies of your sport, and using the right equipment) is another critical component of success that has nothing to do with genetics.

While it is more likely that elite athletes are blessed with great genetics and a great training routine, even recreational athletes can make the most of their ability through optimal conditioning, good nutrition and a positive mental attitude.

By Elizabeth Quinn, at About.com: Sports Medicine

Telomeres – A Window to Your Cellular Age

Uncategorized | Posted by admin June 10th, 2009

Telomeres are sections of genetic material at the end of each chromosome whose primary function is to prevent chromosomal “fraying” when a cell replicates. As a cell ages, its telomeres become shorter. Eventually, the telomeres become too short to allow cell replication, the cell stops dividing and will ultimately die – a normal biological process. Telomere testing can determine the length of your telomeres in relation to your age. This new technology will determine your telomere score based on the calculated length on white blood cells (T-Lymphocytes). Data is compared to a scores from a moving average population of the general population. The higher the telomere score, the “younger” the cells tested. The telomere score is the best direct method to determine biological age using structural analysis of chromosomes. Serial evaluations of telomere length is an indicator of how rapidly one ages relative to the normal population. Therapies can then be directed at slowing the loss of telomere length thus slowing the aging process and age related diseases.
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