Posts Tagged ‘metabolism’

Water: How much needed for health & optimal athletic performance?

Fitness, Recovery - Repair, nutrition, performance | Posted by admin June 27th, 2010

Water is absolutely critical to our body which comprises about 75% water; the brain has 85%, blood 90%, lungs 90%, muscles 75%, kidney 82% and even bones has 22%.  Basically, we are made of water!

Water dissolves the many valuable nutrients, minerals, and chemicals in the biological processes and transports them to different parts of our body. The carbohydrates and proteins that our bodies use as food are metabolized and transported by water in the bloodstream. Water is just as important in the transport of waste and toxins out of our bodies. Without the replenishment of fresh water, our body will fail to function, start to waste away, and finally collapse. An adult loses about 2.5 liters water every day through perspiration, breathing, and elimination (urine and feces), and when the body loses 5% of its total water volume, symptoms of dehydration such as thirst, reduced mental concentration, blurred vision, muscle cramps, unexplained tiredness, irritation, dark urine, will begin to show up.

The consequence of consuming insufficient water can be devastating to our body. The cells will start to draw water from the bloodstream instead, causing the heart to work harder. At the same time, when the kidneys fail to cleanse the blood effectively due to inadequate water, the liver and other organs will have to work harder, putting them under extra stress. Continuous water loss over time will speed up aging but increase risks of diseases and health issues such as constipation, dry and itchy skin, acne, nosebleeds, urinary tract infection, coughs, sneezing, sinus pressure, and headaches.

So, how much water should you drink a day? How much water is enough for you? The minimum amount of water you need depends on our body weight. As a general guide, for two pounds of body weight, an ounce of water is required.  So, if you are 60kg (1 kg is 2.54 lbs), you should drink about 2 liters of water every day.

Specifics of Understanding:

  • Every day you lose water through your breath, perspiration, urine and bowel movements. For your body to function properly, you must replenish its water supply by consuming beverages and foods that contain water. Several approaches attempt to approximate water needs for the average, healthy adult living in a temperate climate.
  • Replacement approach.  The average urine output for adults is about 1.5 liters (6.3 cups) a day.  You lose close to an additional liter of water a day through breathing, sweating and bowel movements.  Food usually accounts for 20 percent of your total fluid intake, so if you consume 2 liters of water or other beverages a day (a little more than 8 cups) along with your normal diet, you will typically replace the lost fluids.  
  • Eight 8-ounce glasses of water a day.  Another approach to water intake is the “8 x 8 rule” — drink eight 8-ounce glasses of water a day (about 1.9 liters). The rule could also be stated, “drink eight 8-ounce glasses of fluid a day,” as all fluids count toward the daily total.  Though the approach isn’t supported by scientific evidence, many people use this basic rule as a guideline for how much water and other fluids to drink.
  • Dietary recommendations. The Institute of Medicine advises that men consume roughly 3 liters (about 13 cups) of total beverages a day and women consume 2.2 liters (about 9 cups) of total beverages a day. Even apart from the above approaches, if you drink enough fluid so that you rarely feel thirsty and produce 1.5 liters (6.3 cups) or more of colorless or slightly yellow urine a day, your fluid intake is probably adequate. Factors that influence water needs: You may need to modify your total fluid intake depending on how active you are, the climate you live in, your health status, and if you’re pregnant or breast-feeding.
  • Exercise. If you exercise or engage in any activity that makes you sweat, you need to drink extra water to compensate for the fluid loss. An extra 400 to 600 milliliters (about 1.5 to 2.5 cups) of water should suffice for short bouts of exercise, but intense exercise lasting more than an hour (for example, running a marathon) requires more fluid intake. How much additional fluid you need depends on how much you sweat during exercise, the duration of your exercise and the type of activity you’re engaged in? During long bouts of intense exercise, it’s best to use a sports drink that contains sodium, as this will help replace sodium lost in sweat and reduce the chances of developing hyponatremia, which can be life-threatening. Also, continue to replace fluids after you’re finished exercising.
  • Environment. Hot or humid weather will make you sweat and requires additional intake of fluid. Heated indoor air also can cause your skin to lose moisture during wintertime. Further, altitudes greater than 8,200 feet (2,500 meters) may trigger increased urination and more rapid breathing, which use up more of your fluid reserves.
  • Illnesses or health conditions. Signs of illnesses, such as fever, vomiting and diarrhea, cause your body to lose additional fluids. In these cases you should drink more water and may even need oral rehydration solutions, such as Gatorade or Poweraid supplements.  Also, you may need increased fluid intake if you develop certain conditions, including bladder infections or urinary tract stones. On the other hand, some conditions such as heart failure and some types of kidney, liver and adrenal diseases may impair excretion of water and even require that you limit your fluid intake.
  • Pregnancy or breast-feeding. Women who are expecting or breast-feeding need additional fluids to stay hydrated. Large amounts of fluid are used especially when nursing. The Institute of Medicine recommends that pregnant women drink 2.3 liters (about 10 cups) of fluids daily and women who breast-feed consume 3.1 liters (about 13 cups) of fluids a day.
  • Other sources.  Although it’s a great idea to keep water within reach at all times, you don’t need to rely only on what you drink to satisfy your fluid needs. What you eat also provides a significant portion of your fluid needs. On average, food provides about 20 percent of total water intake, while the remaining 80 percent comes from water and beverages of all kinds. For example: many fruits and vegetables, such as watermelon and tomatoes, are 90 percent to 100 percent water by weight. Beverages such as milk and juice also are composed mostly of water. Even beer, wine and caffeinated beverages — such as coffee, tea or soda — can contribute, but these should not be a major portion of your daily total fluid intake. Water is one of your best hydration source because it’s calorie-free, inexpensive and naturally available.
  • When to hydrate?   It’s generally not a good idea to use thirst alone as a guide for when to drink. By the time you become thirsty, it’s possible to already be slightly dehydrated. Further, be aware that as you get older your body is less able to sense dehydration and send your brain signals of thirst. Excessive thirst and increased urination can be signs of a more serious medical condition. Talk to your doctor if you experience either. To ward off dehydration and make sure your body has the fluids it needs, make water your beverage of choice. Nearly every healthy adult can consider the following: Drink a glass of water with each meal and between each meal. Hydrate before, during and after exercise. Substitute sparkling water for alcoholic drinks at social gatherings. If you drink water from a bottle, thoroughly clean or replace the bottle often to avoid disease and infections.

 

Drinking too much water?

  • Though uncommon, it is possible to drink too much water. When your kidneys are unable to excrete the excess water, the electrolyte (mineral) content of the blood is diluted, resulting in low sodium levels in the blood, a condition called hyponatremia. Endurance athletes, such as marathon runners, who drink large amounts of water, are at higher risk of hyponatremia. In general, though, drinking too much water is rare in healthy adults who consume an average American diet. If you’re concerned about your fluid intake, check with your doctor or a registered dietitian. He or she can help you determine the amount of water that’s best for you.

 

Staying safely hydrated

Resources:  The Mayo Clinic &
                         Ruth Tan, Health & Nutritional Analyst

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Vitamin D – Its Role in Health & Optimal Athletic Performance

Fitness, Recovery - Repair, nutrition, performance | Posted by admin May 24th, 2010

There are a pandemic number of people who are vitamin D deficient.  This has become evident due to increased discovery and sharing of documentation from clinical trials, epidemiological studies, and educational journals.  The end results from an alarming and growing number due to lack of sunshine exposure and inadequate supply of vitamin D from daily food intake.   This added to obesity trends, an aging population, and improved skin products that block formation of vitamin D3.  Until recently, vitamin D was understood to be solely related to bone mineralization and calcium utilization in the body.   Further studies have revealed vitamin D to play a leading role in many additional cell processes.  More than 36 cell types and 10 extra renal organs have been discovered to possess the vitamin D receptor, or VDR. Insufficient vitamin D is related to reduced immunological conditions, cancers of the breast, colon, pancreas, and prostate as well as heart diseases, type I diabetes, rheumatoid arthritis, cognitive impairment, and all cause mortality.  This impressive collection of medical conditions accounts for more than 60% of all deaths in the Western World.

What is Vitamin D?

A fat soluble pro-hormone, vitamin D is a seco-steroid which exists in two forms:  vitamin D2 & vitamin D3.  Vitamin D2 is obtained from yeast and plant material, vitamin D3 is produced endogenously in the skin by the photo-chemical conversion of 7-dehydrocholesterol. Vitamin D circulates in the body bound to the vitamin D binding protein, or VDBP.  Both vitamin D2 and D3 are converted to the biomarker 25-hydoxyvitamin [D (25(OH)D] in the liver and undergoes further hydroxylation in the kidneys to the bio-active form of the hormone 1,25(OH)2D.

The Frequency of vitamin D Deficiency:

The March 2010 issue of the Journal of Clinical Endocrinology & Metabolism points towards an overwhelming 59% of people that are vitamin D insufficient.  This was based on a cross-sectional study designed to establish a relationship between serum 25(OH)D and the degree of fat penetration in muscle.  These results have been duplicated as well in several independent studies of people from all over the United States in recent months.

Adverse Outcomes of Vitamin D Insufficiency:

Presence of 1,25(OH)2D and vitamin D receptors (VDR) in a wide variety of tissues ranging from pancreas, colon, brain, liver, muscle, skin and lung  speaks of its newly found broad involvement in the functionality of bodily systems.  Published literature over several years indicates that the non-bone mineralization effects of vitamin D are autocrine, not endocrine.  Thus, implying these functions are not based or derived for the amount of circulating 1,25(OH)2D in the body, but rather due to the intracellular synthesis of 1,25(OH)2D by these tissues.  Studies also indicate that the levels of 1,25(OH)2D required for these non-calcemic functions are higher than the levels of normal serum 1,25(OH)2D. 

Epidemiological evidences have linked deprived levels of vitamin D conditions to osteoporosis, osteoarthritis, obesity, multiple sclerosis, hypertension, type I diabetes and several cancers.  Vitamin is also effective in maintaining low susceptibility to infections including pulmonary diseases.

Conclusion:

Vitamin D has been shown to have an extensive area of biological influence due to the discovery of VDR and its conversion in several body tissues.  Health, strength and athletic performance can be optimized by measuring the residual levels of vitamin D at the cellular level to determine the degree of insufficiencies in order to adjust diets and nutritional supplements which directly influences athletic strength and recovery time.

Contact us for information on measuring residual vitamins & minerals by functional intracellular analysis at the cellular level – which is directly proportional to the body stores . . .

Reference:  Ray J, Meike W. D-Light: Vitamin D and Good Health. MLO. 2010;42(5):32-38

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Leptin: How Diabetes & Obesity Are Linked -

Fitness, nutrition | Posted by admin July 5th, 2009

Like two peas in a pod, the obesity and type 2 diabetes epidemics have joined forces in an attempt to ravage America’s health … and it’s working, as hundreds of millions of people have been significantly affected by this deadly pair.

But how are these two epidemics intertwined? Popular belief is that if one eats too much sugar, they’ll get fat and develop diabetes; and, if they don’t get diabetes it’s merely because their body is producing enough insulin to keep up with the sugar. However, researchers have discovered evidence that there’s more to the obesity-diabetes connection than this classic way of thinking: The missing link? Leptin.

Leptin is the way that your fat stores speak to your brain to let your brain know how much energy is available and, very importantly, what to do with it. Studies have shown that leptin plays significant if not primary roles in heart disease, obesity, diabetes, osteoporosis, autoimmune diseases, reproductive disorders, and perhaps the rate of aging itself. Many chronic diseases are now linked to excess inflammation such as heart disease and diabetes. High leptin levels are very pro-inflammatory, and leptin also helps to mediate the manufacture of other very potent inflammatory chemicals from fat cells that also play a significant role in the progression of heart disease and diabetes.

Leptin: A Key Player in Your Health

Leptin plays a far more important role in your health than, for instance, cholesterol, however few doctors are taught to pay attention to it, or even know much about it. Leptin’s critical importance is largely unknown to the medical community because there are no known drugs that regulate its activities and therefore there is no incentive to spend money to educate doctors about leptin’s crucial role in health and disease. The only known way to reestablish proper leptin (and insulin) signaling is via diet and, as such, these can have a more profound effect on your health than any other
known modality of medical treatment. New studies support prior studies that have shown the brain and liver to be of paramount importance in regulating your blood sugar levels especially in type 2 or insulin resistant diabetes. It had been previously believed that the insulin sensitivity of muscle and fat tissues were the most important factor in determining whether one would become diabetic or not. It should be noted that leptin plays a vital role in regulating your brain’s hypothalamic activity which in turn regulates much of our “autonomic” functions; those functions that you don’t necessarily think about but which determines much of your life (and health) such as:

•Body temperature
•Heart rate
•Hunger
•Stress response
•Fat burning or storage
•Reproductive behavior and
•Newly discovered roles in bone growth and blood sugar levels

These studies also illustrate the complexity of hormonal orchestration. Especially with very important hormones like insulin and leptin with far ranging effects, a particular cell can be resistant to one effect while the other stays intact. For instance, it had been shown previously that cells may become resistant to the effects of insulin on glucose influx (which may be protective in limiting the amount of glucose entering cells and thus intracellular glycation), while that same cell may not become resistant to the effects of insulin on cellular proliferation that tell cells to multiply, as these are mediated by two separate pathways. Thus a person with high insulin levels, being insulin resistant in regards to glucose, would still be at a much higher risk of cancer, and this indeed is what happens; high insulin levels are associated with many common forms of cancer. Also, different organ systems become resistant at different rates. Therefore, just taking or artificially raising (by drugs) insulin, and/or leptin, will not correct the problems in the orchestration of the signals, any more than playing the tuba louder will fix mistakes in the written music. However a strategic diet that emphasizes good fats and avoids blood sugar spikes coupled with targeted supplements to enhance insulin and leptin sensitivity by resensitizing your cell’s ability to hear hormonal messages correctly, will allow your life to be the symphony it was meant to be.

REf: Dr.Ron Rosedale

Cell Metabolism March 2005; Vol 1, 169-178 (Free Full-Text Article)

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Leptin & Insulin – Vital Hormones for Optimal Health . . .

nutrition | Posted by admin June 22nd, 2009

Each and every one of us is a combination of lives within lives. We are made up of trillions of individual living cells that each must maintain itself. Even more significantly, the cells must communicate and interact with each other to form a republic of cells that we call our individual self. Our health and life depends on how accurately instructions are conveyed to our cells so that they can act in harmony. It is the communication among the individual cells that will determine our health and our life. The communication takes place by hormones. Arguably therefore, the most important molecules in your body that ultimately will decide your health and life are hormones.

Many would say that genes and chromosomes are the most important molecules, however once born your genes pretty much just sit there; hormones tell them what to do. Certainly, the most important message that our cells receive is how and what to do with energy, and therefore life cannot take place without that.

The two most important hormones that deliver messages about energy and metabolism are insulin and leptin.

Metabolism can roughly be defined as the chemistry that turns food into life, and therefore insulin and leptin are critical to health and disease. Both insulin and leptin work together to control the quality of your metabolism (and, to a significant extent, the rate of metabolism).

Insulin works mostly at the individual cell level, telling the vast majority of cells whether to burn or store fat or sugar and whether to utilize that energy for maintenance and repair or reproduction. This is extremely important for on an individual cell level turning on maintenance and repair equates to increased longevity, and turning up cellular reproduction can increase your risk of cancer.

Leptin, on the other hand, controls the energy storage and utilization of the entire republic of cells allowing the body to communicate with the brain about how much energy (fat) the republic has stored, and whether it needs more, or should burn some off, and whether it is an advantageous time nutritionally-speaking for the republic –you– to reproduce or not.

Leptin is a very powerful and influential hormone produced by fat cells. Prior to leptin’s discovery, fat was viewed as strictly an ugly energy storage depot that most everyone was trying to get rid of. After it was discovered that fat produced the hormone leptin (and subsequently it was discovered that fat produced other very significant hormones), fat became an endocrine organ like the ovaries, pancreas and pituitary, influencing the rest of the body and, in particular, the brain.

Leptin, as far as science currently knows, is the most powerful regulator that tells your brain what to do about life’s two main biological goals: eating and reproduction. Your fat, by way of leptin, tells your brain whether you should be hungry, eat and make more fat, whether you should reproduce and even make babies, or (partly by controlling insulin) whether to “hunker down” and work overtime to maintain and repair yourself. In short, leptin is the way that your fat stores speak to your brain to let your brain know how much energy is available and, very importantly, what to do with it. Therefore, leptin may be “on top of the food chain” in metabolic importance and relevance to disease.

It has been known for many years that fat stores are highly regulated. It appeared that when one tried to lose weight the body would try to gain it back. This commonly results in “yo-yo” dieting and in scientific circles one talks about the “set point” of weight. It has long been theorized that there must be a hormone that determines this.

Science points now to leptin as being that hormone.

If a person is getting too fat, the extra fat produces more leptin which is supposed to tell the brain that there is too much fat stored, more should not be stored, and the excess should be burned.

Signals are therefore sent to an area of the brain in the hypothalamus (the arcuate nucleus) to stop being hungry, to stop eating, to stop storing fat and to start burning some extra fat off.

The importance of insulin in health and disease is becoming well-known. Aside from its obvious role in diabetes, it plays a very significant role in hypertension, cardiovascular disease, and cancer.

However leptin may even supersede insulin in importance, for new research is revealing that in the long run glucose and therefore insulin levels may be largely determined by leptin.

It had been previously believed that the insulin sensitivity of muscle and fat tissues were the most important factor in determining whether one would become diabetic or not. Elegant new studies are showing that the brain and liver are most important in regulating a person’s blood sugar levels especially in type 2 or insulin resistant diabetes.

People become leptin-resistant by the same general mechanism that people become insulin-resistant; by overexposure to high levels of the hormone. High blood glucose levels cause repeated surges in insulin, and this causes one’s cells to become “insulin-resistant” which leads to further high levels of insulin and diabetes. It is much the same as being in a smelly room for a period of time. Soon, you stop being able to smell it, because the signal no longer gets through. This is the same happens with leptin. It has been shown that as sugar gets metabolized in fat cells, fat releases surges in leptin, and those surges result in leptin-resistance just as it results in insulin-resistance.

The only known way to reestablish proper leptin (and insulin) signaling is to prevent those surges, and the only known way to do that is via diet and supplements. When leptin signaling is restored, your brain can finally hear the message that perhaps should have been delivered decades ago; high leptin levels can now scream to your brain that you have too much fat and that you better start burning some off for your life is in danger. Your brain will finally allow you access into your pantry that you have been storing your fat in. Your cells will be fed the food from that fat and they will be satisfied. They will not know whether that food came from your belly fat or from your mouth; nor will they care. They will be receiving energy that they need and will not have to ask for more. You will not be hungry.

This also makes counting calories irrelevant, for the calories that you put into your mouth today are not necessarily what your cells will be eating; that will be determined primarily by leptin. Whether or not you put food into your mouth, your cells will be eating, and if they cannot eat fat they must eat sugar. Since little sugar is stored, that sugar will be had by making you crave it, or by turning the protein in your muscle and bone into sugar. This contributes in a major way to weakness and osteoporosis. Whether or not this lean tissue wasting happens is determined by your capacity, or incapacity, to burn fat, and that is determined by your ability to listen to leptin.

When you become leptin-resistant, your body can no longer hear the messages telling it to stop eating and burn fat — so it remains hungry and stores more fat.

Leptin-resistance also causes an increase in visceral fat, sending you on a vicious cycle of hunger, fat storage and an increased risk of heart disease, diabetes, metabolic syndrome and more.

People become both insulin and leptin resistant by eating the typical
American diet full of sugar,refined grains,processed foods and not a whole lot else. The solution is to instead eat a diet that emphasizes good fats and avoids blood sugar spikes — in short a dietary program detailed which emphasizes healthy fats, lean meats and vegetables, and restricts sugar and grains.

Ref: Ron Rosedale, M.D.

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