Posts Tagged ‘training’

Immune System Response, Exercise and Inflammation

anti-aging, disease, Fitness, nutrition, obesity, Recovery - Repair | Posted by admin December 17th, 2012

Exercise can help boost the body’s immune system. Physical activity can actually produce an inflammatory response, leading to chronic inflammation?

Like other stressors in our lives—allergic reactions, lack of sleep, emotional duress, poor nutritional intake and excess body fat—exercise can directly affect the body’s complex immune system and produce a cascading effect of inflammatory responses.

Inflammation occurs at the peak of the immune response when conditions such as fever trigger the body to increase blood flow and bring in specialized immune cells to help repair and remove damaged tissues.

An acute (short-term) response to internal and external invaders is the basis of a successful immune system. However, when inflammatory stressors become chronic (long-term) and accumulate, trouble begins.

The immune system is divided into two types of responses: natural and specific. The natural response is an all-purpose first line of defense comprising cells that identify and attack a number of different invaders in a short time frame. White blood cells and other cells devour invading pathogens and initiate inflammation by releasing toxic substances that damage and then consume the invader or damaged tissue.

The second component of the immune system, the specific response, is far more complex and mostly beyond the scope of this discussion. Simply put, the specific response recognizes a specific invader, like bacteria or an allergen, and then mounts a defense against it.

This intricate protective mechanism helps maintain the biochemical balance in the body that maintains health or promotes healing. Many body systems must remain balanced for homeostasis to occur. One important example is the endocrine system, which controls much of the body’s regulating hormones, the body’s pH, body temperature and chemicals in the bloodstream, all of which are delicately balanced and vulnerable if altered for a significant length of time.

Physical & Mental Stressors

It should be noted that the immune system is well designed to handle such physical stressors as microbes, sprained ankles and hay fever. What is not clear, however, is how the immune system reacts to the accumulation of other physical stressors—poor nutrition, lack of sleep, food allergies or sensitivities, postural and joint misalignment and foreign substances.

Additionally, behavioral scientists have been examining the effect of mental and emotional stressors. Significant research has indicated that mental stressors provide as great a challenge to homeostasis as physical conditions like influenza or muscle tears.

The term allostatic load refers to the method by which the body adjusts to the combined effect of many physical and mental stressors. A high allostatic load is essentially an overload of those different stressors, creating what one researcher dubbed “a cascade of cause and effect”.

The connecting factor among physical, emotional and mental stressors occurs in an area of the brain known as the HPA axis. Consisting of the hypothalamus, pituitary gland and adrenal gland, the HPA axis serves as the body’s emergency alert system that responds to a variety of stressors by releasing hormones, such as epinephrine and norepinephrine, which prepare different body systems for action. The HPA axis also releases growth hormone (GH) and cortisol; GH helps repair tissue and promotes growth, whereas cortisol fuels the body by maintaining proper glucose and fatty acid levels.

When faced with a lot of different stressors (i.e., a high allostatic load), the intricately tuned immune system can get caught in a stress hormone–inflammation loop. Hormones are released at higher than normal levels, leading to an increase in pro-inflammatory cytokines, which, in a vicious circle, then re-stimulates the HPA axis. Cortisol levels also increase and alter the immune/ inflammation system, resulting in higher levels of inflammatory factors in the body.

Exercise & Inflammation

So how do the immune system, HPA axis and stress response all fit into the exercise and fitness equation? Exercise is a physical stressor, and the exercise stress response follows similar inflammatory physiological pathways to those activated by other physical and mental stimuli.

In fact, the response to exercise is so parallel that exercise scientists borrowed the phrase general adaptation syndrome (GAS) from Hans Selye, a behavioral scientist who pioneered much of the early extensive research on the stress response. According to Selye, stress causes a temporary decrease in function, followed by an adaptation that improves function. In order for us to improve our health, fitness or athletic ability, it is necessary to increase our efforts to fatigue-level intensities and then recover and refuel.

During exercise, the primary hormones that get released are

  • epinephrine (to increase heart rate and blood flow to the muscles)
  • norepinephrine (to raise blood pressure)
  • cortisol (to mobilize fuel sources and lower any inflammation)
  • growth hormone and glucagons (to protect blood glucose and mobilize other energy sources for fuel)

These hormones are the same as those secreted when the body is reacting to mental and emotional stressors.

If the exercise session was designed to elicit higher levels of strength or conditioning, some degree of muscle damage occurred, calling upon the immune system to respond in a number of ways, including an inflammatory response to help muscle repair. While this process promotes muscle regeneration, it can also slow the body’s ability to repair muscle tissue.

Contributing Factors for Inflammation

Many factors play a significant role in increasing body inflammation, including physical imbalances, diet, allergies, sleep deprivation, excess weight and age.

Physical Conditions. Postural and joint mal-alignments play a major role in inflammatory conditions. Exercisers who spend long periods of time sitting each day are especially vulnerable when performing certain upright movements that can create excessive friction in joint complexes. Excessive shoulder internal rotation, thoracic flexion and hip external rotation are classic seated mal-alignment issues that result in pain or damage to areas that then become inflamed.

Poor Diet. One huge contributing factor to inflammation is the Western convenience/comfort food diet, which is high in saturated and trans fats, simple carbohydrates and animal proteins. The American Dietetic Association (ADA) urges Americans to reduce their consumption of saturated and trans fatty acids to diminish risk factors for inflammation-based disorders such as cancer, cardiovascular disease, cerebral infarction and other immune disorders.. Food allergies and sensitivities also contribute to inflammation. The most common food allergies involve wheat gluten, nuts or shellfish. While less severe than allergies, food sensitivities can produce subtle inflammatory reactions to common trigger foods; for example, products made with dairy, corn, soy, wheat, sugar and nuts

Other Allergens. In addition to food, allergens such as chemicals, dust, mold or pollens can cause the body’s immune system to release chemical neurotransmitters called histamines, which trigger an inflammatory process in the blood vessels. The allergic reaction can be slight (e.g., itchy skin, runny nose) or far more serious (e.g., blood pressure drop, swelling, shortness of breath). Environmental pollutants, cleaning products and noise can also increase inflammation.

Sleep Deprivation. Lack of sleep is associated with inflammation. Sleep is a time for the body to recover and repair both mentally and physically. That’s why sleep experts recommend getting 7–9 hours nightly to function optimally. Studies indicate that this time period is critical for biochemical balance in substances like GH and cortisol.

Excess Weight. Biochemical imbalances have also been linked to inflammation caused by excess intra-abdominal fat. Beyond a certain level, excessive intra-abdominal fat produces a cortisol response, which tells the body to store fat; this begins a never-ending feedback loop.

Advanced Age. Another contributing factor is age. As we age, interleukin levels increase dramatically, which plays a role in the development of many diseases of aging, including heart disease, osteoporosis, Alzheimer’s disease and other cognitive impairment diseases.

Tailoring Exercise Programs

Research indicates that high-intensity (> 70% of maximal effort) exercise sessions lasting longer than 20–30 minutes or low-intensity (< 50%–70%) efforts lasting longer than 75 minutes can flood the body with stress and inflammation biochemical markers, initiating a cascading response. It therefore makes sense to devise a workout that stays within those time and intensity parameters.

Moderate exercise at lower intensities is the better course. Moderate exercise efforts for up to 60 minutes can actually reduce inflammatory markers, increase positive neurotransmitters (e.g., serotonin and endorphins) and improve brain chemistry. Moderate intensities also stimulate the growth of new brain cells, neurons and capillary growth to muscles and neurons.

According to most studies, exercising under the 70% effort level seems to be the baseline for reducing inflammation and stress hormone levels These reduced efforts should be combined with exercise programming design that includes myofascial release, flexibility training and corrective exercise. This type of program can help relieve stress, improve joint alignment and muscle activation and reduce the inflammatory response.

Mental Element

It is perfectly acceptable to give less of an effort and work at lower intensities during times of high stress. High-intensity, long-duration workouts are counterproductive if performed during a time of high demands and increased stress in other areas of life.

Managing the hormonal component of exercise can actually help produce gains. The outdated “no pain, no gain” approach can be detrimental to health because at best it stimulates the body to retain body fat or lose muscle mass and at worst it creates a chronic state of injury and illness.

Inflammation also supports the healing power of 7–8 hours of sleep. Sleep is critical to maintaining biochemical homeostasis. The primary function of sleep is to give the body and the mind some restorative time to help decrease systematic inflammation.

Proactive Anti-Inflammatory Strategy

Several proactive anti-inflammatory nutrition strategies that are fairly simple. For example, research has shown that inflammation can be prevented or reduced by the following:

  • adding more fruits and vegetables to the diet
  • reducing intake of trans fats and saturated fats
  • increasing intake of omega-3 fats (found in fish oils, olive oil, avocados and walnuts)
  • reducing intake of simple carbs and animal protein

Some herbs and other phytochemicals have been shown to significantly reduce inflammation in the body. For example, an active component in the herb turmeric called curcumin has been studied extensively for its ability to inhibit cancer cell growth. Ginger has exhibited the same properties. Some dietary supplements combine tumeric, ginger, rosemary, basil and other herbs to create a potent natural anti-inflammatory with no known side effects. Studies have found that this specific combination is as effective as some pharmaceutical compounds at stemming inflammation.

NSAIDs work to inhibit hormones in the body called prostaglandins, which are vital to many physiological processes but specifically cause the sensation of pain as a protective mechanism. Because these hormones are important in gastric function and because NSAIDs eliminate all prostaglandin activity, gastric distress can be a side effect. Newer studies are finding that instead of speeding recovery from muscular injury, ingestion of traditional NSAIDs may actually slow the process for several days as protein synthesis (tissue healing) is delayed.

Common types of traditional NSAIDs include aspirin, ibuprofen, naproxen, ketoprofen and indomethacin. It should be noted that while acetaminophen (Tylenol™) is classified as an NSAID, it exhibits little or no anti-inflammatory effects despite its analgesic properties.

Reference:   IDEA Health & Fitness Association     http://www.ideafit.com

Glutathione: Levels for Health, Strength & Optimal Performance

anti-aging, Fitness, Free Radicals, nutrition, performance, Recovery - Repair | Posted by admin March 30th, 2011

Glutathione is the master anti-oxidant in the body which supports health, enhances tissue and muscle repair,increases strength & endurance and slows the aging of cells.

What can reducing the oxidative process on the body mean for the athlete?

Many world-class athletes are discovering the importance of glutathione, which when maintained, gives them the edge over the competition. Increased glutathione levels provides athletes with increased strength and endurance, decreased recovery time from injury, less pain and fatigue and possibly an increase in muscle-promoting activities. During workouts, athletes generate free radicals which in turn lead to muscle fatigue and poorer performance. Glutathione neutralizes these radicals and allows our bodies to recover faster. Recent research indicates that the body has a natural tendency toward many degenerative diseases and aging itself. Some believe how well the body can protect itself from damage and recover from oxidative damage can be determined by measuring the intracellular stores of Glutathione.

Dietary Choices are the Key

Tumeric:

Scientists have long been aware of the wide array of health benefits from the Indian spice turmeric, which is a source of the active phytochemical curcumin. This bioactive substance of Turmeric (Curcuma Longa) contains “Curcuminoids” and Curcumin is the most important molecule. Research has shown its tremendous health benefit. Antioxidants have received increased attention, and it’s important to know what nutrients are antioxidants, and information about them. One such nutrient is curcumin.  Curcumin is a natural extract from the spice turmeric. Turmeric is derived from the plant Curcuma Longa, a member of the ginger family. Curcumin is employed mostly as an antioxidant; though it was traditionally used to promote stomach and joint comfort. The immune-balancing activity of curcumin has been demonstrated through multiple mechanisms to support normal COX-2 and NF-KappaB levels in the body. The neuroprotective properties of curcumin are among the most studied. Curcumin has been designated as a ‘strong candidate’ for the promotion of neurological health and cognitive function. Curcumin can cross the blood-brain barrier and support the normal uptake of amyloid-beta in the brain. This supports the brain’s memory and learning abilities as we age. Another neuroprotective property of curcumin is its ability to promote normal levels of glutathione, superoxide dismutase and catalase in the brain. This can help to maintain the health of neurological tissues. Curcumin supports the normal production of Phase II liver detoxification enzymes, including glutathione synthase, heme-oxygenase and catalase. The liver plays several roles in detoxification: it filters the blood to remove large toxins, synthesizes and secretes bile full of cholesterol and other fat-soluble toxins, and enzymatically disassembles unwanted chemicals. This enzymatic process usually occurs in two steps referred to as phase I and phase II. They promote the body’s natural enzyme antioxidant defense systems and function as a powerful indirect antioxidant. These enzymes promote the body’s normal metabolism of harmful chemicals such as heavy metals, toxins and pollutants into less reactive molecules. Curcumin has also been shown to promote normal hepatic tissue repair.

Broccoli:

The health benefits and protective properties of broccoli and other cruciferous vegetables have been well documented over the past 25 years. Broccoli is a potent source of sulphoraphane glucosinolates. Sulforaphanes support the normal production of Phase II liver detoxification enzymes, including glutathione synthase, heme-oxygenase and catalase. Sulphoraphanes promote the body’s natural enzyme antioxidant defense systems and function as a powerful indirect antioxidant. Sulphoraphanes work to support gene transcription, which is the process by which genetic information is copied from DNA to RNA, resulting in a specific protein formation. Conclusively, sulphoraphanes work to support the body’s natural defense systems and to maintain elevated levels of glutathione.

Glutathione is the master antioxidant of the body. It is an important chemical that acts as a powerful antioxidant to preserve and protect the brain and other body tissues by protecting them from the damage of free radicals. It also acts to recycle vitamin C & E which also reduce free radicals. Since glutathione cannot be absorbed intact orally due to gastrointestinal degradation, sulphoraphanes may be the most effective way to increase endogenous glutathione concentration.

Selenium:

Selenium is a required cofactor for selenoproteins such as glutathione peroxidase.  Selenomethionine is incorporated directly into proteins because selenomethionine cannot be distinguished from methionine during the translation of mRNA into protein. This serves as a storage form of selenium and is liberated upon protein catabolism. Selenium accumulates in the prostate, promoting the health of the prostate. Selenium supports immune function by promoting normal growth and development of T helper cells.  Selenium is naturally found in walnuts, brazil nuts, seafood, tuna, beef, spaghetti, turkey, eggs, oatmeal, rice, noodles and several types of cheese.

Natural Anti-Inflammatory – Cherries & Exercise Muscle Pain

Free Radicals, nutrition, performance, Recovery - Repair | Posted by admin December 30th, 2010

Drinking cherry juice could help ease the pain for people who run, according to new research from Oregon Health & Science University presented at the American College of Sports Medicine Conference in Seattle, Wash. The study showed people who drank tart cherry juice while training for a long distance run reported significantly less pain after exercise than those who didn’t. Post-exercise pain can often indicate muscle damage or debilitating injuries.

In the study of sixty healthy adults aged 18-50 years, those who drank 10.5 ounces cherry juice (100% tart cherry juice) twice a day for seven days prior to and on the day of a long-distance relay had significantly less muscle pain following the race than those who drank another fruit juice beverage. On a scale from 0 to 10, the runners who drank cherry juice as their “sports drink” had a 2 point lower self-reported pain level at the completion of the race, a clinically significant difference. While more research is needed to fully understand the effects of tart cherry juice, researchers say the early finding indicate cherries may work like common medications used by runners to alleviate post-exercise inflammation. “For most runners, post-race treatment consists of RICE (rest, ice, compression and elevation) and traditional NSAIDS (non-steroidal anti-inflammatory drugs),” said Kerry Kuehl, M.D., a sports medicine physician and principal study investigator. “But NSAIDS can have adverse effects – negative effects you may be able to avoid by using a natural, whole food alternative, like cherry juice, to reduce muscle inflammation before exercise.”

The researchers suggest cherries’ post-exercise benefits are likely because of the fruit’s natural anti-inflammation power – attributed to antioxidant compounds called anthocyanins, which also give cherries their bright red color. Whether elite athletes or weekend warriors, this natural anti-inflammation power of cherry juice could have far-reaching benefits for the millions of active Americans currently taking over-the-counter pain medications to reduce muscle pain and beyond. A growing body of research suggests cherries could affect inflammation related to heart disease, arthritis and may even help maintain muscle strength for those suffering from fibromyalgia (a common, chronic widespread pain disorder), according to a second study presented by the same researchers at the ACSM conference.

It’s Easy to Enjoy “America’s Super Fruit” Cherries are not only good for you, but they’re also a homegrown “Super Fruit.” According to recent data, more than 9 out of 10 Americans want to know where their food comes from, nearly 80 percent say they’re purchasing “locally produced” products, and the majority are defining “local” as made in America. This homegrown advantage, coupled with potential health benefits for athletes, make cherries “America’s Super Fruit.” Tart cherries come in dried, frozen and juice forms so they’re readily available to enjoy all year long.

Kuehl KS, Chestnutt J, Elliot DL, Lilley C. Efficacy of tart cherry juice in reducing muscle pain after strenuous exercise. American College of Sports Medicine. 851. May, 2009.

Jones KD, Elliot DL, Kuehl KS, Dulacki K. Tart cherry juice for fibromyalgia: new testing paradigm and subgroup benefits. American College of Sports Medicine. 852. May, 2009.

Surveys conducted IRI Data and The Hartman Group, 2008 Source:
Caitlin Solway
Weber Shandwick Worldwide

Genetics And Performance

performance | Posted by admin June 12th, 2009

Genetics shape us in many ways including our potential to excel in sports. Training, diet, and other factors play a large role in developing our potential, but our genes may also limit performance. You may have the genetic potential for being a champion athlete, but if you live a lifestyle of overeating and no exercise you are unlikely to achieve that potential. On the other hand, someone with limited genetic potential can find ways to compensate and become a solid performer.

Genetics have a large influence over strength, muscle size and muscle fiber composition (fast or slow twitch), anaerobic Threshold, lung capacity, flexibility, and, to some extent, endurance.

One major limitation for endurance athletes is cardiac capacity, or the heart’s ability to deliver enough oxygen (via the bloodstream) to the working skeletal muscles. This, too, is largely determined by genetics.

The other limitation for endurance athletes is the muscles’ ability to effectively use the oxygen and create ATP (adenosine triphosphate), the fuel that allows muscular contraction and movement. The efficiency of this process is measured by something called VO2 max (maximum volume of oxygen).

How Genetics Influence Response to Training
Your genes may also determine how your body responds to training, diet and other external factors.

Research on aerobic endurance shows that some people respond more to training than others. So even if you have a low genetic potential for endurance, you may respond well to training and develop your potential more completely than someone with genetic ‘talent’ who doesn’t respond to training.

Training also increases cardiac efficiency, but the extent of this increase may depend upon genetics. Genetically gifted athletes will have a much greater response to training and will have a large increase in the number of mitochondria in cells. (The mitochondria are organelles in cells that produce the ATP, so the more mitochondria a person has, and the more efficient they are.)

Other Factors That Affect Performance
Characteristics that genetics have less influence over include balance, agility, reaction time and accuracy.

Nutrition also affects performance. This is clear when even the most highly-trained and gifted athlete bonks during an event. Bonking is usually related to running out of glycogen. Athletes can avoid this either by ‘teaching’ the body to burn fat when glycogen stores decrease, or replenishing the body with nutrition during an event.

Mental Skills Training
Practicing mental skills training (including good judgment, learning the tactics and strategies of your sport, and using the right equipment) is another critical component of success that has nothing to do with genetics.

While it is more likely that elite athletes are blessed with great genetics and a great training routine, even recreational athletes can make the most of their ability through optimal conditioning, good nutrition and a positive mental attitude.

By Elizabeth Quinn, at About.com: Sports Medicine

Vitamin B Deficiency & Poor Athletic Performance Linked

Fitness, performance | Posted by admin April 26th, 2009

Active individuals lacking in B-vitamins – including college athletes and other elite competitors — may perform worse during high-intensity exercise and have a decreased ability to repair and build muscle than counterparts with nutrient-rich diets, according to recent Oregon State University research published in the International Journal of Sport Nutrition and Exercise Metabolism.

The B-vitamins include thiamin, riboflavin, vitamin B-6, B-12 and folate. These micronutrients are necessary during the body’s process for converting proteins and sugars into energy, and are used during the production and repair of cells, including red blood cells. For active individuals a marginal deficiency in the nutrients may impact the body’s ability to repair itself, operate efficiently and fight disease. The stress on the body’s energy producing pathways during exercise, the changes in the body’s tissues resulting from training, an increase in the loss of nutrients in sweat, urine and feces during and after strenuous activity and the additional nutrients needed to repair and maintain higher levels of lean tissue mass present in some athletes and individuals may all affect an individual’s B-vitamin requirements.

“Many athletes, especially young athletes involved in highly competitive sports, do not realize the impact their diets have on their performance. By the time they reach adulthood they can have seriously jeopardized their abilities and their long-term health.”

Current national B-vitamin recommendations for active individuals may be inadequate, and athletes who follow the recommended daily allowances set by the U.S. government may be receiving lower amounts of nutrients than their bodies need. Athletes who restrict calories or limit food groups like dairy or meat have an increased chance of deficiency. Such athletes are often concerned about maintaining a low body weight for sports like gymnastics and wrestling.

The B-vitamins are in whole and enriched grains, dark green vegetables, nuts, and many animal and dairy products. It is suggested athletes and individuals with poor or restricted diets consider taking a multivitamin or mineral supplement.

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Article adapted from original press release by Medical News Today