Posts Tagged ‘weight management’

Immune System Response, Exercise and Inflammation

anti-aging, disease, Fitness, nutrition, obesity, Recovery - Repair | Posted by admin December 17th, 2012

Exercise can help boost the body’s immune system. Physical activity can actually produce an inflammatory response, leading to chronic inflammation?

Like other stressors in our lives—allergic reactions, lack of sleep, emotional duress, poor nutritional intake and excess body fat—exercise can directly affect the body’s complex immune system and produce a cascading effect of inflammatory responses.

Inflammation occurs at the peak of the immune response when conditions such as fever trigger the body to increase blood flow and bring in specialized immune cells to help repair and remove damaged tissues.

An acute (short-term) response to internal and external invaders is the basis of a successful immune system. However, when inflammatory stressors become chronic (long-term) and accumulate, trouble begins.

The immune system is divided into two types of responses: natural and specific. The natural response is an all-purpose first line of defense comprising cells that identify and attack a number of different invaders in a short time frame. White blood cells and other cells devour invading pathogens and initiate inflammation by releasing toxic substances that damage and then consume the invader or damaged tissue.

The second component of the immune system, the specific response, is far more complex and mostly beyond the scope of this discussion. Simply put, the specific response recognizes a specific invader, like bacteria or an allergen, and then mounts a defense against it.

This intricate protective mechanism helps maintain the biochemical balance in the body that maintains health or promotes healing. Many body systems must remain balanced for homeostasis to occur. One important example is the endocrine system, which controls much of the body’s regulating hormones, the body’s pH, body temperature and chemicals in the bloodstream, all of which are delicately balanced and vulnerable if altered for a significant length of time.

Physical & Mental Stressors

It should be noted that the immune system is well designed to handle such physical stressors as microbes, sprained ankles and hay fever. What is not clear, however, is how the immune system reacts to the accumulation of other physical stressors—poor nutrition, lack of sleep, food allergies or sensitivities, postural and joint misalignment and foreign substances.

Additionally, behavioral scientists have been examining the effect of mental and emotional stressors. Significant research has indicated that mental stressors provide as great a challenge to homeostasis as physical conditions like influenza or muscle tears.

The term allostatic load refers to the method by which the body adjusts to the combined effect of many physical and mental stressors. A high allostatic load is essentially an overload of those different stressors, creating what one researcher dubbed “a cascade of cause and effect”.

The connecting factor among physical, emotional and mental stressors occurs in an area of the brain known as the HPA axis. Consisting of the hypothalamus, pituitary gland and adrenal gland, the HPA axis serves as the body’s emergency alert system that responds to a variety of stressors by releasing hormones, such as epinephrine and norepinephrine, which prepare different body systems for action. The HPA axis also releases growth hormone (GH) and cortisol; GH helps repair tissue and promotes growth, whereas cortisol fuels the body by maintaining proper glucose and fatty acid levels.

When faced with a lot of different stressors (i.e., a high allostatic load), the intricately tuned immune system can get caught in a stress hormone–inflammation loop. Hormones are released at higher than normal levels, leading to an increase in pro-inflammatory cytokines, which, in a vicious circle, then re-stimulates the HPA axis. Cortisol levels also increase and alter the immune/ inflammation system, resulting in higher levels of inflammatory factors in the body.

Exercise & Inflammation

So how do the immune system, HPA axis and stress response all fit into the exercise and fitness equation? Exercise is a physical stressor, and the exercise stress response follows similar inflammatory physiological pathways to those activated by other physical and mental stimuli.

In fact, the response to exercise is so parallel that exercise scientists borrowed the phrase general adaptation syndrome (GAS) from Hans Selye, a behavioral scientist who pioneered much of the early extensive research on the stress response. According to Selye, stress causes a temporary decrease in function, followed by an adaptation that improves function. In order for us to improve our health, fitness or athletic ability, it is necessary to increase our efforts to fatigue-level intensities and then recover and refuel.

During exercise, the primary hormones that get released are

  • epinephrine (to increase heart rate and blood flow to the muscles)
  • norepinephrine (to raise blood pressure)
  • cortisol (to mobilize fuel sources and lower any inflammation)
  • growth hormone and glucagons (to protect blood glucose and mobilize other energy sources for fuel)

These hormones are the same as those secreted when the body is reacting to mental and emotional stressors.

If the exercise session was designed to elicit higher levels of strength or conditioning, some degree of muscle damage occurred, calling upon the immune system to respond in a number of ways, including an inflammatory response to help muscle repair. While this process promotes muscle regeneration, it can also slow the body’s ability to repair muscle tissue.

Contributing Factors for Inflammation

Many factors play a significant role in increasing body inflammation, including physical imbalances, diet, allergies, sleep deprivation, excess weight and age.

Physical Conditions. Postural and joint mal-alignments play a major role in inflammatory conditions. Exercisers who spend long periods of time sitting each day are especially vulnerable when performing certain upright movements that can create excessive friction in joint complexes. Excessive shoulder internal rotation, thoracic flexion and hip external rotation are classic seated mal-alignment issues that result in pain or damage to areas that then become inflamed.

Poor Diet. One huge contributing factor to inflammation is the Western convenience/comfort food diet, which is high in saturated and trans fats, simple carbohydrates and animal proteins. The American Dietetic Association (ADA) urges Americans to reduce their consumption of saturated and trans fatty acids to diminish risk factors for inflammation-based disorders such as cancer, cardiovascular disease, cerebral infarction and other immune disorders.. Food allergies and sensitivities also contribute to inflammation. The most common food allergies involve wheat gluten, nuts or shellfish. While less severe than allergies, food sensitivities can produce subtle inflammatory reactions to common trigger foods; for example, products made with dairy, corn, soy, wheat, sugar and nuts

Other Allergens. In addition to food, allergens such as chemicals, dust, mold or pollens can cause the body’s immune system to release chemical neurotransmitters called histamines, which trigger an inflammatory process in the blood vessels. The allergic reaction can be slight (e.g., itchy skin, runny nose) or far more serious (e.g., blood pressure drop, swelling, shortness of breath). Environmental pollutants, cleaning products and noise can also increase inflammation.

Sleep Deprivation. Lack of sleep is associated with inflammation. Sleep is a time for the body to recover and repair both mentally and physically. That’s why sleep experts recommend getting 7–9 hours nightly to function optimally. Studies indicate that this time period is critical for biochemical balance in substances like GH and cortisol.

Excess Weight. Biochemical imbalances have also been linked to inflammation caused by excess intra-abdominal fat. Beyond a certain level, excessive intra-abdominal fat produces a cortisol response, which tells the body to store fat; this begins a never-ending feedback loop.

Advanced Age. Another contributing factor is age. As we age, interleukin levels increase dramatically, which plays a role in the development of many diseases of aging, including heart disease, osteoporosis, Alzheimer’s disease and other cognitive impairment diseases.

Tailoring Exercise Programs

Research indicates that high-intensity (> 70% of maximal effort) exercise sessions lasting longer than 20–30 minutes or low-intensity (< 50%–70%) efforts lasting longer than 75 minutes can flood the body with stress and inflammation biochemical markers, initiating a cascading response. It therefore makes sense to devise a workout that stays within those time and intensity parameters.

Moderate exercise at lower intensities is the better course. Moderate exercise efforts for up to 60 minutes can actually reduce inflammatory markers, increase positive neurotransmitters (e.g., serotonin and endorphins) and improve brain chemistry. Moderate intensities also stimulate the growth of new brain cells, neurons and capillary growth to muscles and neurons.

According to most studies, exercising under the 70% effort level seems to be the baseline for reducing inflammation and stress hormone levels These reduced efforts should be combined with exercise programming design that includes myofascial release, flexibility training and corrective exercise. This type of program can help relieve stress, improve joint alignment and muscle activation and reduce the inflammatory response.

Mental Element

It is perfectly acceptable to give less of an effort and work at lower intensities during times of high stress. High-intensity, long-duration workouts are counterproductive if performed during a time of high demands and increased stress in other areas of life.

Managing the hormonal component of exercise can actually help produce gains. The outdated “no pain, no gain” approach can be detrimental to health because at best it stimulates the body to retain body fat or lose muscle mass and at worst it creates a chronic state of injury and illness.

Inflammation also supports the healing power of 7–8 hours of sleep. Sleep is critical to maintaining biochemical homeostasis. The primary function of sleep is to give the body and the mind some restorative time to help decrease systematic inflammation.

Proactive Anti-Inflammatory Strategy

Several proactive anti-inflammatory nutrition strategies that are fairly simple. For example, research has shown that inflammation can be prevented or reduced by the following:

  • adding more fruits and vegetables to the diet
  • reducing intake of trans fats and saturated fats
  • increasing intake of omega-3 fats (found in fish oils, olive oil, avocados and walnuts)
  • reducing intake of simple carbs and animal protein

Some herbs and other phytochemicals have been shown to significantly reduce inflammation in the body. For example, an active component in the herb turmeric called curcumin has been studied extensively for its ability to inhibit cancer cell growth. Ginger has exhibited the same properties. Some dietary supplements combine tumeric, ginger, rosemary, basil and other herbs to create a potent natural anti-inflammatory with no known side effects. Studies have found that this specific combination is as effective as some pharmaceutical compounds at stemming inflammation.

NSAIDs work to inhibit hormones in the body called prostaglandins, which are vital to many physiological processes but specifically cause the sensation of pain as a protective mechanism. Because these hormones are important in gastric function and because NSAIDs eliminate all prostaglandin activity, gastric distress can be a side effect. Newer studies are finding that instead of speeding recovery from muscular injury, ingestion of traditional NSAIDs may actually slow the process for several days as protein synthesis (tissue healing) is delayed.

Common types of traditional NSAIDs include aspirin, ibuprofen, naproxen, ketoprofen and indomethacin. It should be noted that while acetaminophen (Tylenol™) is classified as an NSAID, it exhibits little or no anti-inflammatory effects despite its analgesic properties.

Reference:   IDEA Health & Fitness Association     http://www.ideafit.com

Sugar is Sugar ??? – Not So . . .

anti-aging, disease, Fitness, nutrition, obesity, performance | Posted by admin November 14th, 2011

Your Brain Reacts to Fructose and Glucose in  Very Different Ways

A study performed at Oregon Health and  Science University is intriguing, as it shows that the difference between  fructose and glucose is not just limited to how they’re metabolized in your  body; your brain also reacts to these two sugars in entirely different ways. Nine healthy, normal-weight subjects  received either glucose, fructose, or saline (as the control). Their brains  were then scanned to evaluate activity around the hypothalamus, which is a key  player in appetite control and production of metabolic hormones. Interestingly, the researchers  discovered that the “cortical control areas” surrounding the  hypothalamus responded very differently to each substance:

  • Glucose significantly raised the level of neural activity for about 20 minutes
  • Fructose reduced neural activity in the area for about the same amount of time
  • Saline had no effect on neural activity

So, what does this mean?

At this point, the implications of these differences are unclear. The Chicago Tribune reported that:

“At this point, said [lead researcher] Purnell in a phone interview, it means nothing more than that the two substances did prompt different responses in the brain–that the brain did not respond to them identically.

Within some of the “cortical control areas” where differences were seen, lie some important neural real estate, including regions where notions of reward and addiction are processed.

As scientists have a closer look in future studies, they should be able to zero in on which specific areas are affected differently by the two forms of sugar.”

So, time will tell what these latest findings really mean, but we already know that fructose has a detrimental impact on two hormones involved with satiety and hunger, namely leptin and ghrelin, and that this influence sets in motion a vicious cycle of hunger, increased food intake, and increased fat storage.

Fructose Packs on the Pounds Faster than Any Other Nutrient

Part of what makes HFCS so unhealthy is that it is metabolized to fat in your body far more rapidly than any other sugar. The entire burden of metabolizing fructose falls on your liver, and it promotes a particularly dangerous kind of body fat, namely adipose fat. This is the fat type of fat that collects in your abdominal region and is associated with a greater risk of heart disease.  Additionally, because most fructose is consumed in liquid form (i.e. soda and sweetened beverages of all kinds), its negative metabolic effects are magnified. Because while HFCS has about the same amount of fructose as cane sugar, the fructose in HFCS is in its “free” form and not attached to any other carbs. The fructose in fruits and in cane sugar is bonded to other sugars which results in a decrease in its metabolic toxicity.

Consuming foods that contain high amounts of fructose—even if it’s a natural product—is, to put it bluntly, the fastest way to trash your health. Among the health problems you invite with a high-fructose diet are:

  • Obesity, insulin resistance, metabolic syndrome and type 2 diabetes
  • Elevated triglycerides and LDL (bad) cholesterol levels
  • Elevated blood pressure
  • Liver disease
  • Depletion of vitamins and minerals—Unbound fructose, found in large quantities in HFCS, can interfere with your heart’s use of minerals such as magnesium, copper and chromium.
  • Cardiovascular disease, arthritis, gout, and cancer

Beware: Mixing Fructose with Glucose Increases Destructive Effect

Fructose consumption clearly causes insulin resistance whereas straight glucose does not. However, it’s worth knowing that glucose accelerates fructose absorption!  So when you mix glucose and fructose together, you absorb more fructose than if  you consumed fructose alone…

This is an important piece of information if you are struggling to control your weight. Remember, sucrose, or table sugar,  is exactly this blend — fructose plus glucose. So, the key to remember is to not get too nit-picky about the names of the sugars. ALL of these contribute to decreased health:

  • Sucrose (table sugar)
  • Corn syrup
  • High fructose corn syrup (HFCS)
  • Crystalline fructose, and any other high-fructose sweetener they may dream up
  • Natural fructose in the form of fruits, fruit juices, and natural sweeteners such as honey and agave.

Is Fructose from HFCS Worse than Fructose from Table Sugar?

High fructose corn syrup is about 55 percent fructose while table sugar is about 50 percent. The fructose in the corn syrup is also dissociated from the glucose, unlike table sugar which has it attached. So HFCS is clearly worse than table sugar, but not orders of
magnitude. It is only marginally worse.

The MAIN reason why fructose and HFCS are so bad is that in the mid 70s two things happened. Earl Butz changed the US Agriculture policy to massively subsidize corn production in the US, and scientists also figured out how to make HFCS in the lab from corn.  The combination of these two events made fructose VERY cheap. So cheap that it’s put in virtually all processed  foods because it is virtually free and massively improves the flavor of most foods. So if you are a processed food producer there are virtually no downsides. So it becomes a QUANTITY issue, and the average person is now consuming 600 percent more than their ancestors did, and some are consuming 1500 percent more. So the massive increase in this toxin is what is causing the problem. If table sugar was as cheap and used as much it would cause virtually identical side effects.

Fructose Metabolism Basics

Without getting into the very complex biochemistry of carbohydrate metabolism, it is important to understand how your body processes glucose versus fructose. Dr. Robert Lustig, Professor of Pediatrics in the Division of Endocrinology at the University of California, has been a pioneer in decoding sugar metabolism. His work has highlighted some major differences in how different sugars are broken down and used.

Here’s a summary of the main points:

  • After eating fructose, 100 percent of the metabolic burden rests on your liver. With glucose, your liver has to  break down only 20 percent.
  • Every cell in your body, including your brain, utilizes glucose. Therefore, much of it is “burned up” immediately after you consume it. By contrast, fructose is turned into free fatty acids (FFAs), VLDL (the damaging form of cholesterol), and triglycerides, which get stored as fat.
  • The fatty acids created during fructose metabolism accumulate as fat droplets in your liver and skeletal muscle tissues, causing insulin resistance and non-alcoholic fatty liver disease (NAFLD). Insulin resistance progresses to metabolic syndrome and type II diabetes.
  • Fructose is the most lipophilic carbohydrate. In other words, fructose converts to activated glycerol (g-3-p), which is directly used to turn FFAs into triglycerides. The more g-3-p you have, the more fat you store. Glucose does not do this.
  • When you eat 120 calories of glucose, less than one calorie is stored as fat. 120 calories of fructose results in 40 calories being stored as fat. Consuming fructose is essentially consuming fat!
  • The metabolism of fructose by your liver creates a long list of waste products and toxins, including a large amount of uric acid, which drives up blood pressure and causes gout.
  • Glucose suppresses the hunger hormone ghrelin and stimulates leptin, which suppresses your appetite. Fructose has no effect on ghrelin and interferes with your brain’s communication with leptin, resulting in overeating.

So, if anyone tries to tell you “sugar is sugar,” they are way behind the times. As you can see, there are major differences in how your body processes each one. The bottom line is: fructose leads to increased belly fat, insulin resistance and metabolic syndrome — not to mention the long list of chronic diseases that directly result.

If you, like so many others, have struggled with your weight for years; examined your diet; avoided fat and counted your calories, yet not getting anywhere and wondering what you’re doing wrong, please pay very close attention to this issue!

In many cases the primary culprit is an excessive intake of hidden sugar in the form of fructose, whether natural fructose (such as agave syrup or 100 percent fruit juice, for example), or in the form of corn syrup (or high fructose corn syrup), which is a main ingredient in countless beverages and processed, pre-packaged foods.  It’s extremely easy to consume high amounts of fructose on a daily basis, especially if most of your foods are processed in any way, or if you drink sodas or any other sweetened beverages  such as ice-teas, fruit juices and sports drinks. As previously discussed, even seemingly “health-conscious” beverages like Vitamin Water, Jamba Juice and Odwalla SuperFood contain far more added sugar and/or fructose than many desserts!  So please, understand that it’s not dietary fat that’s making you fat. It’s fructose.

Recommended Fructose Allowance

As a standard recommendation, keep your TOTAL fructose consumption below 25 grams per day.

For most people it would also be wise to limit your fructose from fruit to 15 grams or less, as you’re virtually guaranteed to
consume “hidden” sources of fructose if you drink beverages other than water and eat processed food. Remember, the average 12-ounce can of soda contains 40 grams of sugar, at least half of which is fructose, so one can of soda ALONE would exceed your  daily allotment.  Fifteen grams of fructose is not much — it represents two bananas, one-third cup of raisins, or two Medjool  dates. In his book, The Sugar Fix, Dr. Johnson includes detailed tables showing the content of fructose in different foods — an information base that isn’t readily available when you’re trying to find out exactly how much fructose is in various foods. We encourage you to pick up a copy of this excellent resource.

Here’s a quick reference list of some of the most common fruits that you can use to help you count your fructose grams:

Limes –                   1 medium = 0 grams
Lemons –                1 medium = 0.6 grams
Cranberries-           1 cup= 0.7 grams
Passion fruit-         1 medium = 0.9 grams
Prune –                     1 medium = 1.2 grams
Apricot –                  1 medium = 1.3 grams
Guava –                    2 medium = 2.2 grams
Date deglet            1 medium = 2.6 grams
Cantaloupe –          1/8 portion = 3.2 grams
Raspberries-         1 cup = 3.0 grams
Clementine –         1 medium = 3.6 grams
Kiwifruit –               1 medium = 3.6 grams
Blackberries –        1 cup = 3.5 grams
Star fruit –              1 medium = 3.6 grams
Cherries sweet –   10 total = 3.8 grams
Strawberries –       1 cup = 3.8 grams
Cherries sour –      1 cup = 4.0 grams
Pineapple –            1 slice = 4.0 grams
Grapefruit pink –  1 half =   4.3 grams
Boysenberries –     1 cup = 4.6 grams
Tangerine –            1 medium = 4.8 grams
Nectarine –             1 medium = 5.4 grams
Peach –                    1 medium = 5.9 grams
Orange navel –       1 medium = 6.1 grams
Papaya –                  1 half = 6.3 grams
Mellon honeydew –  1 eighth = 6.7 grams
Banana –                  1 medium = 7.1 grams
Blueberries –           1 cup = 7.4 grams
Date medjool –       1 medium = 7.7 grams
Apple –                     1 medium = 9.5 grams
Persimmon –           1 medium = 10.6 grams
Watermelon –         1 sixteenth = 11.3 grams
Pear –                       1 medium = 11.8 grams
Raisins –                  1 forth cup = 12.3 grams
Grapes seedless –   1 cup = 12.4 grams
Mango –                   1 half = 16.2 grams
Apricots dried –     1 cup = 16.4 grams
Figs dried –            1 cup = 23.0 grams 

The Way Toward Better Health…

There is nothing benign about the fructose consumption inherent in our modern diet. It is literally supercharged with fructose, and we’re seeing the consequences of this type of eating in our skyrocketing rates of obesity, diabetes, heart disease, and cases of non-fatty liver disease.  Fortunately, there’s plenty of good news here.

There IS a way out of this evil circle, and that is a return to a more holistic diet based on whole foods, along with physical exercise and safe sun exposure to optimize your vitamin D levels.  One of the easiest things you can do to quickly improve your health is to eliminate all soda and sweetened beverages from your life.   ALL soda, because even though HFCS is clearly something you want to avoid, it is still not as bad as artificial sweeteners,  which damage your health even more rapidly than HFCS.  Then, since most processed foods also contain HFCS, avoiding as many processed foods as possible is your next step.
If you want an occasional sweetener, consider:

  1. The herb stevia
  2. Dextrose (pure glucose)

Say no to agave syrup since it is a highly processed sap that is almost all fructose. It is one of the more seriously mismarketed foods in the natural food world. An informal study found the most popular agave brands ranged from 59 to 67 percent pure fructose, far worse than HFCS. Once you realize the hazards of fructose and begin to avoid it in earnest, your diet will significantly improve, which is an essential factor for a long, healthy life.

Reference:  Mercola.com

Sugar is poison to the human body? . . . Why?

anti-aging, Fitness, nutrition, Recovery - Repair | Posted by admin October 13th, 2010

Sugar’s toxic wrath is in part due to its composition as a purely refined carbohydrate.  It is a chemical.  Our bodies cannot utilize this poison because it has been stripped of all vitamins, minerals, and all other nutrients that help your body create optimum health. What occurs when sugar is ingested is a balancing act that takes place inside our bodies.

Because balance or homeostasis is so essential to our bodies, the minerals sodium, potassium, magnesium and calcium are utilized to create this balance.  For example, in order to neutralize the blood from sugar (sugar creates an acidic body), calcium is taken from the bones and teeth, thus, decay and osteoporosis may occur.  If sugar is consumed every day, our bodies eventually will be depleted of these very important minerals and lead to mineral deficiencies that depletes your health and weakens your defenses against disease. This process allows the generation of dreaded free-radicals to cause major damage.  

(Free-radicals lead to cell destruction and single nucleotide polymorphisms at replication during new body cell regeneration)

Excess sugar affects every single organ in the body – including the liver. The liver is where sugar is stored in the form of glycogen (glucose complex).  Eventually, if sugar is consumed every day, your liver will be unable to store the excess sugar and is returned to the blood in the form of fatty acids.  Guess where those fatty acids are stored?  They are stored in the most inactive areas: The belly, the buttocks, the breasts and the thighs.  After these areas have been filled-up, the fatty acids then get distributed to organs such as the heart and kidneys.

Sugar hinders the body’s immune system and predisposes people to illness and disease.  Our white blood cells are adversely affected. Here are just some health conditions associated with over-consumption of sugar: Obesity, cancer, aging, cardiovascular disease, high blood pressure, adult-onset type II diabetes, eczema, kidney stones, depression, Candida (yeast over-growth), anxiety, dental cavities, atherosclerosis, poor brain function and countless other conditions.

Cancer is affected by sugar due to the cancer cell’s main source of fuel:  Glucose. By controlling blood glucose, the cancer cells are starved for fuel and the immune system is bolstered.

We think of sugar as the granulated white stuff, but it can be disguised in many forms such as: corn syrup, fructose, sucrose, lactose, molasses, honey, maltose, fruit juice and many other forms. It is essential that we become aware of the hidden sources of sugar found in processed foods.  In order to achieve optimum health, it is essential to mindfully choose whole grains, fruits, vegetables, lower stress levels, exercise and avoid sugar as much as possible.

Reference: Lori L. Shemek, PhD, CNC, CLC has devoted the past 20 years, practicing and teaching others about the principles of nutrition. As an Author, Health Expert and Speaker, Dr. Shemek combines her background in Psychology with a lifetime of practicing natural and preventive wellness to create optimum health for her clients at every level of health. Dr. Shemek holds a Doctorate in Psychology, she is a Certified Nutritional Consultant, and a Certified Life Coach. Dr. Shemek is the Founder and President of DLS HealthWorks, LLC.  http://www.dlsHealthWorks.com

Leptin: How Diabetes & Obesity are Linked?

Fitness, nutrition | Posted by admin January 21st, 2010

Like two peas in a pod, the obesity and type 2 diabetes epidemics have joined forces in an attempt to ravage America’s health … and it’s working, as hundreds of millions of people have been significantly affected by this deadly pair.

But how are these two epidemics intertwined? Popular belief is that if one eats too much sugar, they’ll get fat and develop diabetes; and, if they don’t get diabetes it’s merely because their body is producing enough insulin to keep up with the sugar. However, researchers have discovered evidence that there’s more to the obesity-diabetes connection than this classic way of thinking: The missing link? Leptin.

Leptin is the way that your fat stores speak to your brain to let your brain know how much energy is available and, very importantly, what to do with it. Studies have shown that leptin plays significant if not primary roles in heart disease, obesity, diabetes, osteoporosis, autoimmune diseases, reproductive disorders, and perhaps the rate of aging itself. Many chronic diseases are now linked to excess inflammation such as heart disease and diabetes. High leptin levels are very pro-inflammatory, and leptin also helps to mediate the manufacture of other very potent inflammatory chemicals from fat cells that also play a significant role in the progression of heart disease and diabetes.

Leptin: A Key Player in Your Health

Leptin plays a far more important role in your health than, for instance, cholesterol, however few doctors are taught to pay attention to it, or even know much about it. Leptin’s critical importance is largely unknown to the medical community because there are no known drugs that regulate its activities and therefore there is no incentive to spend money to educate doctors about leptin’s crucial role in health and disease. The only known way to reestablish proper leptin (and insulin) signaling is via diet and, as such, these can have a more profound effect on your health than any other
known modality of medical treatment. New studies support prior studies that have shown the brain and liver to be of paramount importance in regulating your blood sugar levels especially in type 2 or insulin resistant diabetes. It had been previously believed that the insulin sensitivity of muscle and fat tissues were the most important factor in determining whether one would become diabetic or not. It should be noted that leptin plays a vital role in regulating your brain’s hypothalamic activity which in turn regulates much of our “autonomic” functions; those functions that you don’t necessarily think about but which determines much of your life (and health) such as:

•Body temperature
•Heart rate
•Hunger
•Stress response
•Fat burning or storage
•Reproductive behavior and
•Newly discovered roles in bone growth and blood sugar levels

These studies also illustrate the complexity of hormonal orchestration. Especially with very important hormones like insulin and leptin with far ranging effects, a particular cell can be resistant to one effect while the other stays intact. For instance, it had been shown previously that cells may become resistant to the effects of insulin on glucose influx (which may be protective in limiting the amount of glucose entering cells and thus intracellular glycation), while that same cell may not become resistant to the effects of insulin on cellular proliferation that tell cells to multiply, as these are mediated by two separate pathways. Thus a person with high insulin levels, being insulin resistant in regards to glucose, would still be at a much higher risk of cancer, and this indeed is what happens; high insulin levels are associated with many common forms of cancer. Also, different organ systems become resistant at different rates. Therefore, just taking or artificially raising (by drugs) insulin, and/or leptin, will not correct the problems in the orchestration of the signals, any more than playing the tuba louder will fix mistakes in the written music. However a strategic diet that emphasizes good fats and avoids blood sugar spikes coupled with targeted supplements to enhance insulin and leptin sensitivity by resensitizing your cell’s ability to hear hormonal messages correctly, will allow your life to be the symphony it was meant to be.

Reference: Dr.Ron Rosedale
Cell Metabolism March 2005; Vol 1, 169-178 (Free Full-Text Article)

University of Michigan Study

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