Archive for January, 2010

Leptin: How Diabetes & Obesity are Linked?

Fitness, nutrition | Posted by admin January 21st, 2010

Like two peas in a pod, the obesity and type 2 diabetes epidemics have joined forces in an attempt to ravage America’s health … and it’s working, as hundreds of millions of people have been significantly affected by this deadly pair.

But how are these two epidemics intertwined? Popular belief is that if one eats too much sugar, they’ll get fat and develop diabetes; and, if they don’t get diabetes it’s merely because their body is producing enough insulin to keep up with the sugar. However, researchers have discovered evidence that there’s more to the obesity-diabetes connection than this classic way of thinking: The missing link? Leptin.

Leptin is the way that your fat stores speak to your brain to let your brain know how much energy is available and, very importantly, what to do with it. Studies have shown that leptin plays significant if not primary roles in heart disease, obesity, diabetes, osteoporosis, autoimmune diseases, reproductive disorders, and perhaps the rate of aging itself. Many chronic diseases are now linked to excess inflammation such as heart disease and diabetes. High leptin levels are very pro-inflammatory, and leptin also helps to mediate the manufacture of other very potent inflammatory chemicals from fat cells that also play a significant role in the progression of heart disease and diabetes.

Leptin: A Key Player in Your Health

Leptin plays a far more important role in your health than, for instance, cholesterol, however few doctors are taught to pay attention to it, or even know much about it. Leptin’s critical importance is largely unknown to the medical community because there are no known drugs that regulate its activities and therefore there is no incentive to spend money to educate doctors about leptin’s crucial role in health and disease. The only known way to reestablish proper leptin (and insulin) signaling is via diet and, as such, these can have a more profound effect on your health than any other
known modality of medical treatment. New studies support prior studies that have shown the brain and liver to be of paramount importance in regulating your blood sugar levels especially in type 2 or insulin resistant diabetes. It had been previously believed that the insulin sensitivity of muscle and fat tissues were the most important factor in determining whether one would become diabetic or not. It should be noted that leptin plays a vital role in regulating your brain’s hypothalamic activity which in turn regulates much of our “autonomic” functions; those functions that you don’t necessarily think about but which determines much of your life (and health) such as:

•Body temperature
•Heart rate
•Hunger
•Stress response
•Fat burning or storage
•Reproductive behavior and
•Newly discovered roles in bone growth and blood sugar levels

These studies also illustrate the complexity of hormonal orchestration. Especially with very important hormones like insulin and leptin with far ranging effects, a particular cell can be resistant to one effect while the other stays intact. For instance, it had been shown previously that cells may become resistant to the effects of insulin on glucose influx (which may be protective in limiting the amount of glucose entering cells and thus intracellular glycation), while that same cell may not become resistant to the effects of insulin on cellular proliferation that tell cells to multiply, as these are mediated by two separate pathways. Thus a person with high insulin levels, being insulin resistant in regards to glucose, would still be at a much higher risk of cancer, and this indeed is what happens; high insulin levels are associated with many common forms of cancer. Also, different organ systems become resistant at different rates. Therefore, just taking or artificially raising (by drugs) insulin, and/or leptin, will not correct the problems in the orchestration of the signals, any more than playing the tuba louder will fix mistakes in the written music. However a strategic diet that emphasizes good fats and avoids blood sugar spikes coupled with targeted supplements to enhance insulin and leptin sensitivity by resensitizing your cell’s ability to hear hormonal messages correctly, will allow your life to be the symphony it was meant to be.

Reference: Dr.Ron Rosedale
Cell Metabolism March 2005; Vol 1, 169-178 (Free Full-Text Article)

University of Michigan Study

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CoQ10 – Reduce Muscle Injuries for Athletes?

performance, Recovery - Repair | Posted by admin January 5th, 2010

Marker levels associated with increased wear and tear in the muscle, like creatine kinase and lipid peroxide, were significantly lower in elite Japanese kendo athletes after consuming co-enzyme Q10 for 20 days, compared to placebo.

Researchers from University of Tsukuba, University of Tokyo, and Kobe Gakuin University report their findings in the British Journal of Nutrition.

The study adds to an ever growing body of studies supporting the benefits of the coenzyme for sports nutrition. Only recently, another Japanese group reported that CoQ10 supplements may boost physical performance and reduce feelings of tiredness associated with exercise (Nutrition, doi:10.1016/j.nut.2007.12.007).

CoQ10 has properties similar to vitamins, but since it is naturally synthesized in the body it is not classed as a vitamin. With chemical structure 2,3-dimethoxy-5-methyl-6-decaprenyl-1,4-benzoquinone, it is also known as ubiquinone because of its ‘ubiquitous’ distribution throughout the human body.

The level of CoQ10 produced by the body begins to drop after the age of about 20, and the coenzyme is concentrated in the mitochondria – the ‘power plant’ of body cells. It plays a vital role in the production of chemical energy by participating in the production of adenosince triphosphate (ATP), the body’s so-called ‘energy currency’.

Beyond it’s participation with mitochondria CoQ10 acts as a potent antioxidant. The coenzyme plays an important role in preserving levels of vitamin E and vitamin C.

kendo athletic study

Michihiro Kon and co-workers recruited 18 elite Japanese kendo student athletes and randomly assigned them to receive daily supplements of CoQ10 (300 mg) or placebo for 20 days. The study was double-blind, meaning neither volunteers nor researchers knew who was receiving the active or placebo dose. The volunteers had daily training sessions of five and a half hours per day for six days during the intervention period. At day three and five of the six day training period, the researchers report that both groups experienced increased in serum creatine kinase activity and the concentration of myoglobin, but these increases were significantly lower in the group receiving the CoQ10 supplements.

Creatine kinase is an enzyme that catalyses the conversion of creatine to phosphocreatine, in the process consuming adenosine triphosphate (ATP) and generating adenosine diphosphate (ADP). Elevated levels of the enzyme are indicative of muscle damage and injury. Moreover, levels of lipid peroxide, a marker of oxidative stress, were also lower in the CoQ10 group after three and five days of training, said the researchers.

“These results indicate that CoQ10 supplementation reduced exercise-induced muscular injury in athletes”

Mechanism

The underlying mechanism appears to be due to the antioxidant potential of the coenzyme, suggest the researchers, although further research is necessary to confirm these findings.

Source: British Journal of Nutrition
“Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10”
Authors: M. Kon, K. Tanabe, T. Akimoto, F. Kimura, Y. Tanimura, K. Shimizu, T. Okamoto, I. Kono